Publications

Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth

Painter, C. D., Sankaranarayanan, N. V., Nagarajan, B., Clausen, T. M., West, A. M. V., Setiawan, N. J., Park, J., Porell, R. N., Bartels, P. L., Sandoval, D. R., Vasquez, G. J., Chute, J. P., Godula, K., Vander Kooi, C. W., Gordts, P. L. S. M., Corbett, K. D., Termini, C. M., Desai, U. R., and Esko, J. D. ACS Chemical Biology. 2024, 19, 1820-1835.

Glycocalyx engineering with heparan sulfate mimetics attenuates Wnt activity during adipogenesis to promote glucose uptake and metabolism

Trieger, G. W.; Pessentheiner, A. R.; Purcell, S. C.; Green, C. R.; DeForest, N.; Willert, K.; Majithia, A. R.; Metallo, C. M.; Godula, K.;*  Gordts, P.L.S.M.* J. Biol. Chem. 2023, 299, 104611. 

Cell surface photoengineering enables modeling of glycocalyx shedding dynamics

Purcell, S. C.; Zhang, M. H.; Honigfort, D. J.; Ng, H. J. C.; Michalak, A. L.; Godula, K.* Chem. Sci. 2022, 13, 6626-6635. 

PABP1 Drives the Selective Translation of Influenza A Virus mRNA

de Rozières, C. M.; Pequeno, A.; Shahabi, S.; Lucas, T. M.; Godula, K.; Ghosh, G.; Joseph, S. J. Mol. Biol. 2022, 434:167460. 

Stem Cell Microarrays for Assessing Growth Factor Signaling in Engineered Glycan Microenvironments

Michalak, A. L.; Trieger, G. W.; Trieger, K. A.; Godula, K.* Adv. Healthc. Mater. 2022, 11, e2101232.39. 

Biologically-derived neoproteoglycans for profiling protein-glycosaminoglycan interactions

Porell, R.; Follmar, J.; Purcell, S.; Timm, B.; Laubach, L.; Kozirovskiy, D.; Thacker, B.; Glass, C.; Gordts, P.L.S.M. ; Godula, K.* ACS Chem. Biol. 2022, 17, 1534–1542. 

Glycocalyx crowding with mucin mimetics strengthens binding of soluble and virus-associated lectins to host cell glycan receptors

Honigfort, D. J.; Altman, M. O.; Gagneux, P.; Godula, K.* Proc. Nat’l. Acad. Sci. 2021, 118. DOI: 10.1073/pnas.2107896118 41. 

Mucin-mimetic glycan arrays integrating machine learning for analyzing receptor pattern recognition by influenza A viruses

Lucas, T. M.; Gupta, C.; Altman, M. O.; Sanchez, E.; Naticchia, M. R.; Gagneux, P.; Singharoy, A.; Godula, K.* Chem. 2021, 7, 3393-3411. 

Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate

Weiss R.J.; Spahn P.N.; Chiang A.W.T;, Liu Q.; Li J.; Hamill K.M.; Rother S.; Clausen T.M.; Hoeksema M.A.; Timm B.M.; Godula K.; Glass C.K.; Tor Y.; Gordts P.L.S.M.; Lewis N.E.; Esko J.D. Nat. Chem. Biol. 2021, 17, 684-692. 

Spatially controlled glycocalyx engineering for growth factor patterning in embryoid bodies

Naticchia, M. R.; Laubach, L. K.; Honigfort, D. J.; Purcell, S. C. Godula, K.* Biomater Sci. 2021, 9, 1652-1659. 

CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2

Clausen, T. M., Sandoval, D. R.; Spliid, C. B.; Pihl, J.; Painter, C. D.; Thacker, B. E; Glass, C. A.;  Narayanan, A.; Majowicz, S. A.; Zhang, Y.; Torres, J. L.;  Golden, G. J.;  Porell, R.; Garretson, A. F.; Laubach, L. K.;  Feldman, J.; Yin, X.; Pu, Y.;  Hauser, B.; Caradonna, T. M.;  Kellman, B. P.; Martino, C; Gordts, P. L. S. M.; Leibel, S. L.; Chanda, S. K.; Schmidt, A. G.; Godula, K.;  Jose, J.; Corbett, K. D.; Ward, A. B.; Carlin, A. F.; Esko, J. D.* SARS- Cell. 2020, 183, 1043-105736. 

Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

Honigfort, D. J.; Zhang, M. H.; Verespy, S.; Godula, K.* Faraday Discuss. 2019, 219, 138-1532019. 

Efficient Synthesis of Heparinoid Bioconjugates for Tailoring FGF2 Activity at the Stem Cell-Matrix Interface

Trieger, G.W.; Verespy, S.; Gordts, P.L.S.M.; Godula, K.* Bioconjug Chem. 30, 833-840 (2019). 

Embryonic stem cell engineering with glycomimetic FGF2 and BMP4 co-receptor drives mesodermal differentiation in 3D culture

Naticchia, M.; Laubach, L.K.; Tota, E. M.; Lucas,T. M.; Huang, M. L.; Godula, K.* ACS Chem Biol. 13, 2880-2887 (2018). 

Influencing early stages of neuromuscular junction formation through glycocalyx engineering

Huang, M.L., Tota, E. M.; Lucas, T. M.; Godula, K.* ACS Chem. Neurosci. 9, 3086–3093 (2018). 

Small molecule antagonist of cell surface glycosaminoglycans restricts embryonic stem cells in a pluripotent state

Huang, M. L.; Michalak, A. L.; Fisher, C. J.; Christy, M.; Smith, R. A. A.; Godula, K.* Stem Cells 36, 45-54 (2017). 

Heparin-fibronectin interactions in the development of extracellular matrix insolubility

Raitman, I.; Huang, M. L.; Williams, S. A.; Friedman, B.; Godula, K.; Schwarzbauer, J. E. Matrix Biol. 67, 107-122 (2017). 

Glycocalyx scaffolding with synthetic nanoscale glycomaterials

Huang, M. L.; Purcell, S. C.; Verespy, S.; Wang, Y.; Godula, K.* Biomater. Sci. 5, 1537-1540 (2017). 

Human milk oligosaccharides inhibit growth of group B Streptococcus

Lin, A. E.; Autran, C. A.; Szyszka, A.; Escajadillo, T.; Huang, M. L.; Godula, K.; Prudden, A. R.; Boons, G.; Lewis, A.L.; Doran, K.S.; Nizet, V.; Bode, L. J. Biol. Chem. 292, 11243-11249 (2017). 

Synthetic mucus nanobarriers for identification of glycan-dependent primary Influenza A infection inhibitors.

Cohen, M.*; Senaati, H.; Fisher, C. J.; Huang, M.; Gagneux, P.; Godula, K.* ACS Central Sci. 2, 710-714 (2016). 

Capture and characterization of influenza A virus from primary samples using glycan bead arrays

Cohen, M.; Fisher, C. J.; Huang, M. L.; Lindsay, L. L.; Plancarte, M.; Boyce, W. M.; Godula, K.; Gagneux, P. Virology 493, 128-35 (2016). 

Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays

Huang, M. L.; Cohen, M.; Fischer, C. J.; Schooley, R. T.; Gagneux, P.; Godula, K.* Chem. Commun. 51, 5326-5329 (2015) [Selected for the 2015 Emerging Investigators issue of the journal] 

Glycocalyx remodeling with proteoglycan mimetics promotes neural specification in embryonic stem cells

Huang, M. L.; Smith, R. A.; Trieger, G. W.; Godula, K.* J. Am. Chem. Soc. 136, 10565-10568 (2014). [Highlighted in the Chemical and Engineering News] 

The Cancer Glycocalyx Mechanically Primes Integrin-Dependent Growth and Survival

Paszek, M. J.; Dufort, C. C.; Rossier, O.; Bainer, R.; Mouw, J. K.; Godula, K.; Hudak, J. E. Lakins, J. N.; Wijekoon, A.; Cassereau, L.; Rubashkin, M. G.; Magbanua, M. J.; Thorn, K. S.; Davidson, M. W.; Rugo, H. S.; Park, J. W.; Hammer, D. A.; Giannone, G.; Bertozzi, C. R.; Weaver, V. M. Nature. 511, 319-325 (2014). 

Chemoenzymatic Fc Glycosylation via Engineered Aldehyde Tags

Smith, E. L.; Giddens, J.P.; Iavarone, A. T., Godula, K., Wang, L-X, Bertozzi, C. Bioconjugate Chem. 25, 788-795 (2014). [Selected as an Editor’s Choice article] 

Modulation of Ocular Surface Glycocalyx Barrier Function by a Galectin-3 N-terminal Deletion Mutant and Membrane-Anchored Synthetic Glycopolymers
Mauris J, Mantelli F, Woodward AM, Cao Z, Bertozzi CR, Panjwani N, Godula K, Argueso P. PLoS ONE 19; 8(8):e72304 (2013).

Density Variant Glycan Microarray for Evaluating Crosslinking of Mucin‐like Glycoconjugates by Lectins

Godula, K.; Bertozzi, C. R. J. Am. Chem. Soc. 134, 15732‐15742 (2012). 

Synthesis of Glycopolymers for Microarray Applications via Ligation of Reducing Sugars to a Poly(acryloyl hydrazide) Scaffold

Godula, K.; Bertozzi, C. R. J. Am. Chem. Soc. 132, 9963‐9965 (2010). 

Control of the Molecular Orientation of Membrane‐Anchored Biomimetic

Godula, K.; Umbel, M. L.; Rabuka, D.; Botyanszki, Z.; Bertozzi, C. R.; Parthasarathy, R. Glycopolymers. J. Am. Chem. Soc. 131, 10263‐10268 (2009). 

Synthesis and Microcontact Printing of Dual End‐Functionalized Mucin‐like Glycopolymers for Microarray Applications

Godula, K.; Rabuka, D.; Nam, K. T.; Bertozzi, C. R. Angew. Chem. Int. Ed. 48, 4973‐4976 (2009). 

Expeditious Synthesis of Contorted Hexabenzocoronenes

Plunkett, K. N.; Godula, K.; Nuckolls, C.; Tremblay, N.; Whalley, A. C.; Xiao, S. Org. Lett. 11, 2225‐2228 (2009). 

Iron‐Mediated Preparation of Vinylcyclopropanecarboxylates: Scope, Mechanism, and Applications
Yun, Y. K.; Godula, K.; Cao, Y.; Donaldson, W. A. J. Org. Chem. 68, 901‐910 (2003).

C‐C Bond Formation via C-H Bond Activation: Synthesis of the Core of Teleocidin B4
Dangel, B. D.; Godula, K.; Youn, S. W.; Sezen, B.; Sames, D.  J. Am. Chem. Soc. 124, 11856‐11857 (2002).

A Simple and Efficient Synthesis of Optically Pure Tricarbonyl(methyl 6‐oxo‐2,4‐hexadienoate)iron
Godula, K.; Baermann, H.; Donaldson, W. A. J. Org. Chem. 66, 3590‐3592 (2001).

Synthesis of Cyclopropanes via Organoiron Methodology: Preparation of 2‐(2'‐carboxy‐3'‐ethylcyclopropyl)glycine
Godula, K.; Donaldson, W. A. Tetrahedron Lett. 42, 153‐154 (2001).